/*efficacy Page*/

  /*********Tabs starts here************/
  #copd-clinical-trials-data #resources-tabs,
  #copd-clinical-trials-data #resources-tabs,
  #copd-clinical-trials-data #resources-tabs {
    position: relative;
  }

  #copd-clinical-trials-data #tabs-block ol.cmp-tabs__tablist,
  #copd-clinical-trials-data #tabs-block ol.cmp-tabs__tablist,
  #copd-clinical-trials-data #tabs-block ol.cmp-tabs__tablist {
    max-width: 100%;
    margin: 0 auto;
  }

  #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab,
  #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab,
  #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab {
    font-family: 'Avenir-Medium';
    font-size: 16px;
    line-height: 20px;
    font-weight: 800;
    color: #121312;
    border: 3px solid #FFFFFF;
    background: #F5F5F5;
    border-radius: 48px;
    padding: 11px 17px 9px 17px;
    width: 280px;
    text-align: center;
  }

  #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab--active,
  #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab--active,
  #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab--active {
    background: #227870;
    color: #FFFFFF;
    border: 3px solid #FFFFFF;
  }



  /************Tabs ends here**********/

  .efficacy-banner {
    padding: 0;
  }

  .efficacy-banner-in {
    padding: 20px 0 29px 0;
  }

  .efficacy-banner-content {
    padding: 0; 
  }

  .efficacy-banner-content a {
    display: inline-block;
    padding: 5px 15px 3px 15px;
    border: 2px solid #F0B323;
    border-radius: 100px;
    font-family: 'Avenir-Black';
    font-size: 14px;
    line-height: 20px;
    color: #121312; 
    margin: 0 0 13px 0;
  }

  .efficacy-banner-content h1 {
    font-family: 'Avenir-Medium';
    font-size: 40px;
    line-height: 44px;
    font-weight: 800;
    color: #121312;
    margin: 0 0 11px 0;
  }

  .efficacy-banner-content p {
    font-family: 'Avenir-Medium';
    font-size: 16px;
    line-height: 24px;
    font-weight: 800;
    color: #373A36;
  }

  /*********ETHOS Primary Endpoint Css starts here**************/
  .ethos-primary-main {
    padding: 0px 0 56px 0;
    margin-top: 50px;
  }

  .ethos-primary-inner {
    display: flex;
    padding: 32px 48px;
    align-items: flex-start;
    gap: 0px;
    border-radius: 16px;
    background: #F5F5F5;
    max-width: 1200px;
  }

  .ethos-primary-endpoint {
    max-width: 196px;
    margin-right: 50px;
  }

  .ethos-in-study {
    max-width: 805px;
    padding: 0 0 0 51px;
    position: relative;
  }

  .ethos-primary-endpoint p {
    color: #121312;
    font-family: 'Avenir-Medium';
    font-size: 28px;
    font-weight: 800;
    line-height: 32px;
    max-width: 201px;
  }

  .ethos-in-study p {
    font-family: 'Avenir-Book';
    font-size: 24px;
    line-height: 32px;
    color: #121312;
  }

  .ethos-in-study::before {
    content: '';
    position: absolute;
    left: 0;
    top: 0;
    background: #B4B8B2;
    width: 2px;
    height: 100%;
    border-radius: 16px;
  }

  .ethos-primary-endpoint p span {
    display: block;
  }

  /*********ETHOS Primary Endpoint Css ends here**************/
  /*********Secondary Endpoint Endpoint Css starts here*********/
  .efficacy-secondary-endpoint-main {
    padding: 0px;
  }

  .efficacy-secondary-endpoint-inner {
    padding: 24px 0px;
    max-width: 1200px;
  }

  .efficacy-secondary-endpoint-hearder h4 {
    color: #121312;
    text-align: center;
    font-family: 'Avenir-Black';
    font-size: 32px;
    font-weight: 800;
    line-height: 38px;
    margin-bottom: 6px;
  }

  .efficacy-secondary-endpoint-hearder p {
    color: #121312;
    text-align: center;
    font-family: 'Avenir-Book';
    font-size: 32px;
    font-weight: 350;
    line-height: 38px;
  }

  .efficacy-secondary-endpoint-img {
    background-repeat: no-repeat;
    background-size: contain;
    max-width: 1172px;
    margin: 62px 78px 0px;
  }

  .efficacy-nonsignificant-txt {
    max-width: 940px;
    margin: 0 auto;
    padding: 60px 10px 5px 5px;
  }

  .efficacy-nonsignificant-txt p {
    color: #121312;
    font-family: 'Avenir-Book';
    font-size: 16.5px;
    font-style: normal;
    font-weight: 800;
    line-height: 24px;
  }

  .efficacy-nonsignificant-txt p:nth-child(1),
  .efficacy-nonsignificant-txt p:nth-child(2) {
    margin-bottom: 20px;
  }

  /*********Secondary Endpoint Endpoint Css ends here*********/
  /*********Efficacy efficacy-sample Css starts here**************/
  .efficacy-sample {
    display: flex;
    align-items: center;
    justify-content: space-between;
    padding: 64px 0 72px 0;
  }

  .efficacy-sample-button {
    width: 49%;
  }

  .efficacy-sample-button a {
    background: #F0B323;
    border: 1px solid #F0B323;
    border-radius: 16px;
    position: relative;
    display: block;
    padding: 12px 20px 12px 23px;
    color: #121312;
  }

  .efficacy-sample-button a::after {
    content: "";
    background: url(/content/dam/intelligentcontent/brands/breztri-hcp/us/en/images/desktop/safety/icon-chevron-right.svg);
    display: inline-block;
    width: 28px;
    height: 28px;
    background-repeat: no-repeat;
    right: 31px;
    position: absolute;
    top: 50%;
    transform: translateY(-50%);
    -webkit-transform: translateY(-50%);
    -moz-transform: translateY(-50%);
    -ms-transform: translateY(-50%);
    -o-transform: translateY(-50%);
  }

  .efficacy-sample-button a:hover {
    background: #F5CC6C;
    border: #F5CC6C 1px solid;
  }

  .efficacy-sample-button2 a {
    background: #227870;
    border: #227870 1px solid;
    color: #FFFFFF;
  }

  .efficacy-sample-button2 a:hover {
    background: #2B978D;
    border: #2B978D 1px solid;
    color: #FFFFFF;
  }

  .efficacy-sample-button2 a::after {
    background: url(/content/dam/intelligentcontent/brands/breztri-hcp/us/en/images/desktop/safety/icon-chevron-right-white.svg);
  }

  .efficacy-sample-content {
    display: flex;
    align-items: center;
  }

  .efficacy-sample-view img {
    width: 56px;
  }

  .efficacy-sample-text {
    padding: 0 20px 0 20px;
  }

  .efficacy-sample-text span {
    font-family: 'Avenir-Medium';
    font-size: 24px;
    line-height: 30px;
    font-weight: 800;
  }

  .efficacy-cumulative {
    background: #F5F5F5;
    padding: 14px 48px;
    border-radius: 8px;
    margin: 0px 45px 60px 45px;
  }

  .efficacy-cumulative p {
    font-family: 'Gotham-Book';
    font-size: 14px;
    line-height: 20px;
    color: #121312;
  }

  .efficacy-secondary-endpoint-img figcaption {
    font-family: 'Avenir-Medium';
    font-size: 15px;
    text-align: center;
    margin-left: 13%;
    line-height: 24px;
  }

  /*********Efficacy efficacy-sample Css end here**************/

  /*********Tab-3 Reference Css start here**************/
  #copd-clinical-trials-data #effi-word-break {
    /* word-break: break-all; */
    font-family: 'Avenir-Book';
    font-size: 14px;
    line-height: 20px;
    color: #373A36;
    padding: 0px;
    position: relative;
    font-weight: 400;
  }

  /*********Tab-3 Reference Css end here**************/
  @media screen and (min-width: 1600px) {
    /*.efficacy-banner-main {
      height: 18vw;
    } */
  }

  @media screen and (max-width: 991px) {
 
     
    .efficacy-banner-content h1 {
      font-size: 32px;
      line-height: 37px;
    }

    #copd-clinical-trials-data .efficacy-banner-main,
    #copd-clinical-trials-data .efficacy-banner-main,
    #copd-clinical-trials-data .efficacy-banner-main {
      min-height: 254px;
    }

   

    #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab,
    #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab,
    #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab {
      display: block;
      width: 100%;
    }

    #copd-clinical-trials-data #faq-accordion,
    #copd-clinical-trials-data #faq-accordion,
    #copd-clinical-trials-data #faq-accordion {
      padding: 0 15px;
    }



    #copd-clinical-trials-data #tabs-block ol.cmp-tabs__tablist,
    #copd-clinical-trials-data #tabs-block ol.cmp-tabs__tablist,
    #copd-clinical-trials-data #tabs-block ol.cmp-tabs__tablist {
      max-width: 360px;
      margin: 0 auto;
    }

    #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab,
    #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab,
    #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab {
      font-family: 'Avenir-Medium';
      font-size: 16px;
      line-height: 20px;
      font-weight: 800;
      border-radius: 16px;
      padding: 10px 42px;
      width: 360px;
      text-align: center;
    }

    #copd-clinical-trials-data #tabs-block .cmp-tabs__tablist li:nth-child(3) {
      Padding: 20px;
    }

    #copd-clinical-trials-data #effi-word-break {
      word-break: break-all;
      font-family: 'Avenir-Book';
      font-size: 14px;
      line-height: 20px;
      color: #373A36;
      padding: 0px;
      position: relative;
      font-weight: 400;
    }


    /*********ETHOS Primary Endpoint Css starts here*******/
    .ethos-primary-inner {
      padding: 20px 24px 32px 24px;
      gap: 0;
    }

    .ethos-primary-endpoint p {
      font-size: 18px;
      line-height: 24px;
      max-width: 100%;
    }

    .ethos-in-study p {
      font-size: 16px;
      line-height: 24px;
    }

    .ethos-in-study p::before {
      content: "";
      display: block;
      background: #B4B8B2;
      width: 100%;
      height: 2px;
      margin-bottom: 16px;
      margin-top: 16px;
    }

    .ethos-in-study::before {
      display: none;
    }

    .ethos-in-study {
      padding: 0;
    }

    .ethos-primary-main {
      padding: 0px;
      margin-top: 32px;
    }

    .ethos-primary-inner {
      flex-direction: column;
      align-items: flex-start;
    }

    .ethos-primary-endpoint {
      max-width: 100%;
    }

    .ethos-in-study {
      max-width: 100%;
    }

    .efficacy-nonsignificant-txt .magnifier-pop-out {
      text-align: center;
    }

    #copd-clinical-trials-data .modal-exacer,
    #copd-clinical-trials-data .modal-exacer #copd-clinical-trials-data .modal-exacer {
      display: none;
    }

    #copd-clinical-trials-data .modal-exacer,
    #copd-clinical-trials-data .modal-exacer,
    #copd-clinical-trials-data .modal-exacer {
      display: none;
      position: fixed;
      z-index: 1;
      padding-top: 100px;
      left: 0;
      top: 0;
      width: 100%;
      height: 100%;
      overflow: auto;
      background-color: rgb(18 19 18 / 72%);
    }

    #copd-clinical-trials-data .modal-content,
    #copd-clinical-trials-data .modal-content,
    #copd-clinical-trials-data .modal-content {
      background-color: #fefefe;
      margin: 190px auto;
      border: 1px solid #888;
      max-width: 97%;
    }

    #copd-clinical-trials-data .report-data-exacer img,
    #copd-clinical-trials-data .report-data-exacer img,
    #copd-clinical-trials-data .report-data-exacer img {
      padding: 5px 10px 5px 5px;
    }

    #copd-clinical-trials-data .modal-content .close,
    #copd-clinical-trials-data .modal-content .close,
    #copd-clinical-trials-data .modal-content .close {
      background-color: rgb(245 245 245 / 32%);
      color: #ffffff;
      float: right;
      font-size: 48px;
      width: 48px;
      height: 48px;
      text-align: center;
      position: absolute;
      right: 4%;
      margin-top: -62px;
      border-radius: 50%;
    }

    #copd-clinical-trials-data .close:hover,
    #copd-clinical-trials-data .close:focus,
    #copd-clinical-trials-data .close:hover,
    #copd-clinical-trials-data .close:focus,
    #copd-clinical-trials-data .close:hover,
    #copd-clinical-trials-data .close:focus {
      color: #ffffff;
      text-decoration: none;
      cursor: pointer;
    }

    .efficacy-secondary-endpoint-img {
      margin: 20px 10px 0px 0px;
    }

    #copd-clinical-trials-data #tabs-block .report-data-exacer,
    #copd-clinical-trials-data #tabs-block .report-data-exacer,
    #copd-clinical-trials-data .report-data-exacer {
      margin: 0 auto;
      text-align: center;
    }

    /*********ETHOS Primary Endpoint Css ends here*******/
    /*********Secondary Endpoint Endpoint Css starts here*********/

    .efficacy-secondary-endpoint-hearder h4 {
      padding-top: 16px;
      color: #121312;
      text-align: left;
      font-size: 24px;
      font-weight: normal;
      line-height: 38px;
    }

    .efficacy-secondary-endpoint-hearder p {
      color: #121312;
      text-align: left;
      font-size: 24px;
      line-height: normal;
      font-weight: 350;
    }

    .efficacy-secondary-endpoint-inner {
      padding: 26px 0px 0px 0px;
    }

    /*********Secondary Endpoint Endpoint Css ends here*********/

    /*********Efficacy efficacy-sample Css starts here**************/
    .efficacy-sample {
      display: block;
      padding: 0px 0 42px 0;
    }

    .efficacy-sample-button {
      width: 100%;
      margin: 0 0 26px 0;
    }

    .efficacy-sample-button2 {
      margin: 0;
    }

    .efficacy-sample-text span {
      font-size: 18px;
      line-height: 24px;
    }

    .efficacy-sample-view img {
      width: 48px;
    }

    .efficacy-sample-button a {
      padding: 10px 10px 10px 15px;
    }

    .efficacy-sample-button a::after {
      right: 17px;
    }

    .efficacy-sample-text {
      padding: 0 10px 0 10px;
    }

    .efficacy-cumulative {
      padding: 14px 20px;
      margin: 0px 0px 30px 0px;
    }

    .efficacy-nonsignificant-txt {
      padding: 0px 10px 8px 5px;
    }

    /*********Efficacy efficacy-sample Css end here**************/

    /*********Tab-3 Reference Css start here**************/
    #copd-clinical-trials-data #effi-word-break {
      /* word-break: break-all; */
      font-family: 'Avenir-Book';
      font-size: 14px;
      line-height: 20px;
      color: #373A36;
      padding: 0px;
      position: relative;
      font-weight: 400;
    }

    /*********Tab-3 Reference Css end here**************/
  }


  /****Efficacy Tab-1 Desktop CSS starts here****/

  /****Efficacy Tab-1 heading Css starts here****/
  .efficacy-tab-one-main {
    padding: 54px 0 47px 0;
  }

  .efficacy-tab-one-inner h2 {
    color: #121312;
    text-align: center;
    font-family: 'Avenir-Medium';
    font-size: 32px;
    font-weight: 800;
    line-height: 38px;
  }

  /****Efficacy Tab-1 heading Css ends here****/

  /****Efficacy Tab-1 kronos Css start here****/
  .kronos-tab-one-main {
    padding: 0px 0 60px 0;
  }

  .kronos-tab-one-inner {
    display: flex;
    padding: 32px 48px;
    align-items: flex-start;
    gap: 96px;
    border-radius: 16px;
    background: #F5F5F5;
    max-width: 1200px;
  }

  .kronos-tab-one-primary {
    max-width: 207px;
  }

  .kronos-tab-one-study {
    max-width: 847px;
    padding: 0 0 0 48px;
    position: relative;
  }

  .kronos-tab-one-primary p {
    color: #121312;
    font-family: 'Avenir-Medium';
    font-size: 28px;
    font-weight: 800;
    line-height: 32px;
  }

  .kronos-tab-one-study::before {
    content: '';
    position: absolute;
    left: 0;
    top: 0;
    background: #B4B8B2;
    width: 2px;
    height: 100%;
    border-radius: 16px;
  }

  .kronos-tab-one-study p {
    color: #121312;
    font-family: 'Avenir-Book';
    font-size: 24px;
    line-height: 32px;
  }

  /****Efficacy Tab-1 kronos Css end here****/

  /****Efficacy Tab-1 triple-therapy Css start here****/
  .triple-therapy-tab-one-main {
    padding: 0 0 80px 0;
  }

  .triple-therapy-tab-one-inner {
    display: flex;
    gap: 97px;
    margin: 0 auto;
    max-width: 900px;
  }

  .triple-therapy-tab-one-left {
    max-width: 570px;
  }

  .triple-therapy-tab-one-right {
    max-width: 221px;
    margin: 0 auto;
  }

  .triple-therapy-tab-one-left-majority {
    padding: 0 0 0px 0;
  }

  .triple-therapy-tab-one-left-majority p {
    color: #121312;
    font-family: 'Avenir-Book';
    font-size: 18px;
    line-height: 24px;
  }

  .triple-therapy-tab-one-left-reduction {
    padding: 0 0 28px 0;
  }

  .triple-therapy-tab-one-left-reduction p {
    color: #121312;
    font-family: 'Avenir-Medium';
    font-size: 28px;
    font-weight: 800;
    line-height: 32px;
  }

  .triple-therapy-tab-one-left-ics-laba {
    padding: 0px 0 0px 22px;
    position: relative;
    margin: 0 0 28px 0;
  }

  .triple-therapy-tab-one-left-ics-laba::before {
    content: '';
    position: absolute;
    left: 0;
    top: 0;
    background: #F0B323;
    width: 3px;
    height: 100%;
    border-radius: 16px;
  }

  .triple-therapy-tab-one-left-ics-laba p {
    color: #121312;
    font-family: 'Avenir-Medium';
    font-size: 19px;
    font-weight: 800;
    line-height: 24px;
  }

  .triple-therapy-tab-one-left-ics-laba p.triple-therapy-ratio {
    color: #121312;
    font-family: 'Avenir-Book';
    font-size: 14px;
    line-height: 20px;
  }

  .triple-therapy-tab-one-left-ics-laba .triple-therapy-annual {
    padding: 8px 0 0 0;
  }

  .triple-therapy-tab-one-left-ics-laba .triple-therapy-annual p {
    color: #121312;
    font-family: 'Avenir-Medium';
    font-size: 15px;
    font-weight: 800;
    line-height: 20px;
  }

  .triple-therapy-footnotes {
    position: relative;
    max-width: 451px;
  }

  .triple-therapy-footnotes p {
    color: #121312;
    font-family: 'Avenir-Book';
    font-size: 14px;
    line-height: 20px;
    padding: 0px 0 0 5px;
  }

  .triple-therapy-footnotes p span {
    left: 0px;
    position: absolute;
  }

  .triple-therapy-exacerbation p.triple-therapy-number {
    color: #121312;
    font-family: 'Avenir-Black';
    font-size: 98px;
    line-height: 83px;
  }

  .triple-therapy-exacerbation span.triple-therapy-percentage {
    color: #121312;
    font-family: 'Avenir-Black';
    font-size: 49px;
    line-height: normal;
  }

  .triple-therapy-exacerbation {
    display: flex;
    flex-direction: column;
    align-items: center;
    justify-content: center;
  }

  .triple-therapy-exacerbation p.triple-therapy-lama {
    color: #121312;
    text-align: center;
    font-family: 'Avenir-Medium';
    font-size: 23px;
    font-weight: 800;
    line-height: 28px;
  }

  .triple-therapy-exacerbation span.unadjust {
    display: inline-block;
  }

  .triple-therapy-exacerbation p.triple-therapy-rate {
    color: #121312;
    text-align: center;
    font-family: 'Avenir-Book';
    font-size: 16px;
    line-height: 24px;
  }

  .triple-therapy-down-arrow figure {
    margin: 0;
  }

  .triple-therapy-down-arrow {
    position: relative;
    margin: -15px 0 15px 0;
  }

  .triple-therapy-right-footnotes {
    position: relative;
    max-width: 207px;
    margin: 0 auto;
    display: block;
  }

  .triple-therapy-right-footnotes p {
    color: #121312;
    font-family: 'Avenir-Book';
    font-size: 14px;
    line-height: 20px;
  }

  .triple-therapy-right-footnotes p span {
    position: absolute;
    left: -5px;
  }

  .triple-therapy-right-footnotes-mobile {
    display: none;
  }

  /****Efficacy Tab-1 triple-therapy Css end here****/

  /****Efficacy Tab-1 kronos-study-design Css start here****/
  .kronos-study-design-tab-one-main {
    padding: 0 0 27px 0;
  }

  .kronos-study-design-tab-one-inner {
    max-width: 1104px;
    margin: 0 auto;
  }

  .kronos-study-design-heading p {
    color: #121312;
    font-family: 'Avenir-Medium';
    font-size: 32px;
    font-weight: 800;
    line-height: 38px;
  }

  .kronos-study-design-footnotes p {
    color: #121312;
    font-family: 'Avenir-Book';
    font-size: 16px;
    line-height: 24px;
  }

  .kronos-study-design-footnotes p::before {
    content: "";
    display: block;
    background: #E8EAE8;
    width: 100%;
    height: 2px;
    margin-top: 16px;
    margin-bottom: 36px;
  }

  /****Efficacy Tab-1 kronos-study-design Css end here****/

  /****Efficacy Tab-1 auc footnote Css start here****/
  .auc-tab-one-footnote-main {
    padding: 0 0 27px 0;
  }

  .auc-tab-one-footnote-inner {
    display: flex;
    max-width: 1104px;
    justify-content: center;
    align-items: center;
    margin: 0 auto;
    border-radius: 8px;
    background: #F5F5F5;
  }

  .auc-tab-one-footnote-content {
    padding: 14px 32px;
  }

  .auc-tab-one-footnote-content p {
    color: #121312;
    font-family: 'Gotham-Book';
    font-size: 14px;
    line-height: 20px;
  }

  /****Efficacy Tab-1 auc footnote Css end here****/

  /****Efficacy Reference Tab-1 Css start here****/
  #copd-clinical-trials-data #effi-word-break {
    word-break: break-all;
    font-family: 'Avenir-Book';
    font-size: 14px;
    line-height: 20px;
    color: #373A36;
    padding: 0px;
    position: relative;
    font-weight: 400;
  }

  /****Efficacy Reference Tab-1 Css end here****/

  /****Efficacy Tab-1 Desktop CSS ends here****/

  /****Efficacy Tab-1 Mobile CSS starts here****/

  @media screen and (max-width: 991px) {

    /****Efficacy Tab-1 heading Css starts here****/
    .efficacy-tab-one-main {
      padding: 32px 0 28px 0;
    }

    .efficacy-tab-one-inner h2 {
      text-align: left;
      font-size: 24px;
      line-height: normal;
    }

    /****Efficacy Tab-1 heading Css ends here****/

    /****Efficacy Tab-1 kronos Css start here****/
    .kronos-tab-one-main {
      padding: 0px 0 26px 0;
    }

    .kronos-tab-one-inner {
      flex-direction: column;
      gap: 0;
      padding: 24px 20px 32px 20px;
    }

    .kronos-tab-one-primary {
      max-width: 100%;
      margin-bottom: 16px;
    }

    .kronos-tab-one-study {
      max-width: 100%;
      padding: 16px 0 0 0;
    }

    .kronos-tab-one-study::before {
      content: '';
      position: absolute;
      left: 0;
      top: 0;
      background: #B4B8B2;
      width: 100%;
      height: 2px;
      border-radius: 16px;
    }

    .kronos-tab-one-primary p {
      font-size: 18px;
      line-height: 24px;
    }

    .kronos-tab-one-study p {
      font-size: 16px;
      line-height: 24px;
    }

    /****Efficacy Tab-1 kronos Css ends here****/

    /****Efficacy Tab-1 triple-therapy Css start here****/
    .triple-therapy-tab-one-main {
      padding: 0 0 44px 0;
      gap: 40px;
    }

    .triple-therapy-tab-one-inner {
      flex-direction: column;
    }

    .triple-therapy-tab-one-left-reduction p {
      font-size: 20px;
      line-height: 26px;
    }

    .triple-therapy-tab-one-left-majority {
      padding: 0 0 0px 0;
    }

    .triple-therapy-tab-one-left-reduction {
      padding: 0 0 26px 0;
    }

    .triple-therapy-tab-one-left-ics-laba {
      padding: 0px 0 0px 19px;
      margin: 0 0 32px 0;
    }

    .triple-therapy-tab-one-inner {
      gap: 0px;
    }

    .triple-therapy-tab-one-right {
      max-width: 183px;
    }

    .triple-therapy-exacerbation p.triple-therapy-number {
      font-size: 82px;
    }

    .triple-therapy-exacerbation span.triple-therapy-percentage {
      font-size: 42px;
    }

    .triple-therapy-exacerbation p.triple-therapy-lama {
      font-size: 19px;
      line-height: 25px;
      max-width: 159px;
    }

    .triple-therapy-exacerbation p.triple-therapy-rate {
      font-size: 14px;
      line-height: 20px;
    }

    .triple-therapy-right-footnotes {
      display: none;
    }

    .triple-therapy-right-footnotes-mobile {
      display: block;
      position: relative;
      max-width: 585px;
      margin: 0 auto;
      padding: 0 0 26px 0;
    }

    .triple-therapy-right-footnotes-mobile p {
      color: #121312;
      font-family: 'Avenir-Book';
      font-size: 14px;
      line-height: 20px;
    }

    .triple-therapy-right-footnotes-mobile p span {
      position: absolute;
      left: -5px;
    }

    .triple-therapy-down-arrow {
      margin: -10px 0 24px 0;
    }

    /****Efficacy Tab-1 triple-therapy Css ends here****/

    /****Efficacy Tab-1 kronos-study-design Css start here****/
    .kronos-study-design-tab-one-main {
      padding: 0 0 20px 0;
    }

    .kronos-study-design-heading p {
      font-size: 24px;
      line-height: normal;
    }

    .kronos-study-design-footnotes p::before {
      margin-top: 12px;
      margin-bottom: 38px;
    }

    /****Efficacy Tab-1 kronos-study-design Css end here****/

    /****Efficacy Tab-1 auc footnote Css start here****/
    .auc-tab-one-footnote-main {
      padding: 0 0 47px 0;
    }

    .auc-tab-one-footnote-content {
      padding: 14px 20px;
    }

    /****Efficacy Tab-1 auc footnote Css end here****/

    /****Efficacy Tab-1 Sample CTA buttons Css start here****/
    #copd-clinical-trials-data .sample {
      display: block;
      padding: 36px 0 36px 0;
    }

    /****Efficacy Tab-1 Sample CTA buttons Css end here****/

    /****Efficacy Tab-2 Reference Css start here****/
    #copd-clinical-trials-data #effi-word-break {
      word-break: break-all;
      font-family: 'Avenir-Book';
      font-size: 14px;
      line-height: 20px;
      color: #373A36;
      padding: 0px;
      position: relative;
      font-weight: 400;
    }

    /****Efficacy Tab-2 Reference Css end here****/
  }

  @media screen and (max-width: 415px) {
    .triple-therapy-tab-one-left-reduction {
      max-width: 345px;
    }
  }

  /****Efficacy Tab-1 Mobile CSS ends here****/

  /****Efficacy Tab-2 Desktop CSS starts here****/

  /****Efficacy Tab-2 dual-therapies heading Css starts here****/
  .dual-therapies-tab-two-main {
    padding: 54px 0 74px 0;
  }

  .dual-therapies-tab-two-inner {
    padding: 50px 48px 32px 48px;
    border-radius: 16px;
    background: #F5F5F5;
    max-width: 1200px;
  }

  .dual-therapies-tab-two-heading {
    max-width: 723px;
    padding: 0 0 56px 0;
    display: none;
  }

  .dual-therapies-tab-two-heading h2 {
    color: #121312;
    font-family: 'Avenir-Medium';
    font-size: 32px;
    font-weight: 800;
    line-height: 38px;
  }

  .dual-therapies-ethos-tab-two-inner {
    display: flex;
    align-items: flex-start;
    gap: 98px;
  }

  .dual-therapies-ethos-tab-two-primary {
    max-width: 142px;
  }

  .dual-therapies-ethos-tab-two-primary p {
    color: #121312;
    font-family: 'Avenir-Medium';
    font-size: 28px;
    font-weight: 800;
    line-height: 32px;
  }

  .dual-therapies-ethos-tab-two-study {
    max-width: 853px;
    padding: 0 0 0 48px;
    position: relative;
  }

  .dual-therapies-ethos-tab-two-study::before {
    content: '';
    position: absolute;
    left: 0;
    top: 0;
    background: #B4B8B2;
    width: 2px;
    height: 100%;
    border-radius: 16px;
  }

  .dual-therapies-ethos-tab-two-study p {
    color: #121312;
    font-family: 'Avenir-Book';
    font-size: 24px;
    line-height: 32px;
  }

  /****Efficacy Tab-2 dual-therapies heading Css ends here****/
  /****Efficacy Tab-2 big-num-circle Css start here****/
  .big-num-circle-tab-two-main {
    padding: 0 0 75px 0;
  }

  .big-num-circle-tab-two-inner {
    max-width: 1004px;
    margin: 0 auto;
  }

  .big-num-circle-heading {
    padding: 0 0 26px 0;
  }

  .big-num-circle-heading p {
    color: #121312;
    font-family: 'Avenir-Medium';
    font-size: 32px;
    font-weight: 800;
    line-height: 38px;
  }

  .big-num-circle-tab-two-inner-box {
    display: flex;
    gap: 135px;
  }

  .big-num-circle-tab-two-left {
    display: flex;
    gap: 31px;
  }

  .big-num-circle-one {
    max-width: 235px;
    background-image: linear-gradient(to right, #B6F8F2, #2CD5C4);
    border-radius: 117px;
    height: 235px;
    width: 235px;
    display: flex;
    align-items: center;
    justify-content: center;
    margin: 25px 0 0 0;
  }

  .big-num-circle-one p {
    color: #42454A;
    font-family: 'Avenir-Black';
    font-size: 207px;
    line-height: normal;
  }

  .big-num-additional-content {
    max-width: 196px;
    margin: 0 auto;
  }

  .big-num-lungs {
    max-width: 120px;
    padding: 0 0 8px 0;
  }

  .big-num-lungs figure {
    margin: 0;
  }

  .big-num-lungs-content {
    max-width: 182px;
    padding: 0 0 0 14px;
  }

  .big-num-lungs-content p {
    color: #373A36;
    font-family: 'Avenir-Medium';
    font-size: 24px;
    font-weight: 800;
    line-height: 29px;
  }

  .big-num-circle-tab-two-right {
    display: flex;
    gap: 0px;
    flex-direction: column;
  }

  .big-num-circle-tab-two-right-top {
    display: flex;
    gap: 24px;
  }

  .big-num-circle-tab-two-right-bottom {
    display: flex;
    gap: 24px;
  }

  .big-num-groups {
    max-width: 284px;
  }

  .big-num-groups-icon {
    max-width: 43px;
    margin: 5px 0 0 0;
  }

  .big-num-groups-icon figure {
    margin: 0;
  }

  .big-num-lama-laba p {
    color: #42454A;
    font-family: 'Avenir-Black';
    font-size: 105px;
    line-height: normal;
  }

  .big-num-groups-content {
    max-width: 279px;
  }

  .big-num-groups-content p {
    color: #121312;
    font-family: 'Avenir-Book';
    font-size: 16px;
    line-height: 24px;
  }

  .big-num-circle-border-line {
    content: "";
    display: block;
    width: 100%;
    height: 2px;
    margin-top: 25px;
    margin-bottom: 18px;
    border-radius: 16px;
    background: #E8EAE8;
    max-width: 373px;
  }

  .big-num-circle-tab-two-right span {
    color: #121312;
    font-family: 'Avenir-Medium';
    font-size: 16px;
    font-weight: 800;
    line-height: 24px;
  }

  .big-num-lama-laba {
    max-width: 120px;
    background-image: linear-gradient(to right, #B6F8F2, #2CD5C4);
    border-radius: 60px;
    height: 120px;
    width: 120px;
    display: flex;
    align-items: center;
    justify-content: center;
  }

  .big-num-ics-laba {
    max-width: 120px;
    background-image: linear-gradient(to right, #B6F8F2, #2CD5C4);
    border-radius: 60px;
    height: 120px;
    width: 120px;
    display: flex;
    align-items: center;
    justify-content: center;
  }

  .big-num-ics-laba p {
    color: #42454A;
    font-family: 'Avenir-Black';
    font-size: 105px;
    line-height: normal;
  }

  .big-num-groups-ics-laba {
    max-width: 284px;
  }

  .big-num-groups-ics-laba-icon {
    max-width: 88px;
  }

  .big-num-groups-ics-laba-content p {
    color: #121312;
    font-family: 'Avenir-Book';
    font-size: 16px;
    line-height: 24px;
  }

  .big-num-groups-ics-laba-icon figure {
    margin: 0;
  }

  .big-num-circle-border-bottom {
    display: none;
  }

  .treated-main {}

  .treated-block {
    max-width: 1004px;
    margin: 0 auto;
    padding: 0 0 55px 0;
  }

  .treated-head {
    padding: 0 0 40px 0;
  }

  .treated-head h2 {
    color: #121312;
    font-family: 'Avenir-Medium';
    font-size: 32px;
    font-weight: 800;
    line-height: 38px;
  }

  .treated-head p {
    color: #121312;
    font-family: 'Avenir-Medium';
    font-size: 32px;
    font-weight: 800;
    line-height: 38px;
  }

  .prevemt-block {
    max-width: 939px;
    margin: 0 auto;
  }

  .prevemt {
    display: flex;
    align-items: center;
    justify-content: space-between;
    padding: 0 0 20px 0;
  }

  .prevemt-treated-in figure {
    margin: 40px 0 0 0;
  }

  .prevemt-treated-in h5 {
    color: #121312;
    font-family: 'Avenir-Medium';
    font-size: 28px;
    font-weight: 800;
    line-height: 38px;
    margin: 0 0 20px 0;
  }

  .prevemt-treated-in h5 span {
    font-family: 'Avenir-Book';
    font-weight: normal;
  }

  .prevemt-content {
    align-items: center;
    display: flex;
  }

  .prevemt-content>span {
    max-width: 235px;
    background-image: linear-gradient(90deg, #B6F8F2 0%, #2CD5C4 100%);
    border-radius: 100%;
    height: 123px;
    width: 123px;
    display: flex;
    align-items: center;
    justify-content: center;
    color: #42454A;
    font-family: 'Avenir-Black';
    font-size: 108px;
    padding: 10px 0 0 0;

  }

  .prevemt-content>p {
    color: #121312;
    font-family: 'Avenir-Medium';
    font-size: 24px;
    line-height: 29px;
    padding: 0 0 0 25px;
    max-width: 285px;
    font-weight: 800;
  }

  .prevemt-treated-in p span {
    font-family: 'Avenir-Medium';
    font-weight: 800;
  }

  .prevemt-treated-block1 .prevemt-content p {
    max-width: 152px;
  }

  .prevemt-treated-block2 {
    padding: 0 10px;
  }

  .additional-prevemt {
    padding: 20px 0 20px 0;
  }

  .additional-prevemt p {
    color: #121312;
    font-family: 'Avenir-Book';
    font-size: 24px;
    line-height: 29px;
  }

  .additional-prevemt p span {
    font-family: 'Avenir-Medium';
    font-weight: 800;
  }

  .additional-note {
    padding: 15px 0;
    border-top: 2px solid #00D9C4;
  }

  .additional-note p {
    color: #121312;
    font-family: 'Avenir-Book';
    font-size: 16px;
    line-height: 29px;
  }




  /****Efficacy Tab-2 big-num-circle Css ends here****/

  /****Efficacy Tab-2 event-based-ntt Css start here****/
  .event-based-ntt-tab-two-main {
    padding: 0 0 97px 0;
  }

  .event-based-ntt-tab-two-inner {
    border-radius: 8px;
    background: #DEFFFC;
    align-items: center;
    display: flex;
    max-width: 940px;
    margin: 0 120px;
  }

  .event-based-ntt-content {
    position: relative;
    padding: 20px 26px 16px 19px;
  }

  .event-based-ntt-content::before {
    content: '';
    position: absolute;
    left: 0;
    top: 0;
    background: #2CD5C4;
    width: 8px;
    height: 100%;
    border-radius: 16px;
  }

  .event-based-ntt-content p {
    color: #121312;
    font-family: 'Avenir-Book';
    font-size: 24px;
    line-height: 32px;
  }


  /****Efficacy Tab-2 event-based-ntt Css ends here****/

  /****Efficacy Tab-2 Ethos design Css ends here****/
  .ethos-design-tab-two-main {
    padding: 0 0 19px 0;
  }

  .ethos-design-tab-two-inner {
    max-width: 1104px;
    margin: 0 auto;
  }

  .ethos-design-content p {
    color: #121312;
    font-family: 'Avenir-Medium';
    font-size: 32px;
    font-weight: 800;
    line-height: 38px;
  }

  .ethos-design-content p::after {
    content: "";
    display: block;
    background: #E8EAE8;
    width: 100%;
    height: 2px;
    margin-top: 16px;
    margin-bottom: 46px;
    border-radius: 16px;
  }

  .ethos-design-sub-content p {
    color: #121312;
    font-family: 'Avenir-Book';
    font-size: 16px;
    line-height: 24px;
  }


  /****Efficacy Tab-2 Ethos design Css ends here****/

  /****Efficacy Tab-2 Patient-population Css start here****/
  .patient-population-tab-two-main {
    padding: 20px 0 20px 0;
  }

  .patient-population-tab-two-inner {
    max-width: 1104px;
    margin: 0 auto;
  }

  .patient-population-content {
    padding: 0px 0px 0 0px;
  }

  .patient-population-content p {
    color: #121312;
    font-family: 'Avenir-Book';
    font-size: 16px;
    line-height: 24px;
  }

  /****Efficacy Tab-2 Patient-population Css end here****/

  /****Efficacy Tab-2 Patients-footnote Css start here****/
  .patients-footnote-tab-two-main {
    padding: 0 0 16px 0;
  }

  .patients-footnote-tab-two-inner {
    display: flex;
    max-width: 1104px;
    justify-content: center;
    align-items: center;
    margin: 0 auto;
    border-radius: 8px;
    background: #F5F5F5;
  }

  .patients-footnote-content {
    padding: 14px 32px;
  }

  .patients-footnote-content p {
    color: #121312;
    font-family: 'Gotham-Book';
    font-size: 14px;
    line-height: 20px;
  }

  #copd-clinical-trials-data .sample {
    padding: 64px 0 68px 0;
  }

  /****Efficacy Tab-2 Reference Css start here****/
  #copd-clinical-trials-data #effi-word-break {

    font-family: 'Avenir-Book';
    font-size: 14px;
    line-height: 20px;
    color: #373A36;
    padding: 0px;
    position: relative;
    font-weight: 400;
  }

  /****Efficacy Tab-2 Reference Css end here****/
  /****Efficacy Tab-2 Patients-footnote Css end here****/

  @media screen and (max-width: 1100px) {
    .big-num-circle-tab-two-inner-box {
      display: flex;
      gap: 77px;
    }
  }

  /****Efficacy Tab-2 Desktop CSS starts here****/

  /****Efficacy Tab-2 Mobile CSS starts here****/
  @media screen and (max-width: 991px) {

    /****Efficacy Tab-2 dual-therapies heading Css starts here****/
    .dual-therapies-tab-two-main {
      padding: 23px 0 51px 0;
    }

    .dual-therapies-tab-two-inner {
      padding: 24px 20px 24px 20px;
    }

    .dual-therapies-tab-two-heading h2 {
      font-size: 24px;
      line-height: normal;
    }

    .dual-therapies-ethos-tab-two-inner {
      gap: 0;
      flex-direction: column;
    }

    .dual-therapies-ethos-tab-two-study {
      padding: 16px 0 0 0;
    }

    .dual-therapies-tab-two-heading {
      max-width: 723px;
      padding: 0 0 16px 0;
    }

    .dual-therapies-ethos-tab-two-primary {
      max-width: 100%;
      margin-bottom: 16px;
    }

    .dual-therapies-ethos-tab-two-primary p {
      font-size: 18px;
      line-height: 24px;
    }

    .dual-therapies-ethos-tab-two-study::before {
      width: 100%;
      height: 2px;
    }

    .dual-therapies-ethos-tab-two-study p {
      font-size: 16px;
      line-height: 24px;
    }

    /****Efficacy Tab-2 dual-therapies heading Css end here****/

    /****Efficacy Tab-2 big-num-circle Css start here****/
    .big-num-circle-tab-two-main {
      padding: 0 0 50px 0;
    }

    .big-num-circle-heading {
      padding: 0 0 24px 0;
    }

    .big-num-circle-heading p {
      font-size: 24px;
      line-height: normal;
    }

    .big-num-circle-tab-two-inner-box {
      flex-direction: column;
      gap: 43px;
      padding: 0 0 0 7px;
    }

    .big-num-circle-tab-two-left {
      display: flex;
      gap: 18px;
    }

    .big-num-circle-one {
      max-width: 91px;
      border-radius: 45px;
      height: 91px;
      width: 91px;
      margin: 0;
    }

    .big-num-circle-one p {
      font-size: 81px;
      line-height: normal;
    }

    .big-num-additional-content {
      max-width: 216px;
      margin: 0;
    }

    .big-num-lungs-content span.additional-or {
      display: inline-block;
    }

    .big-num-lungs-content span.additional-for {
      display: inline-block;
    }

    .big-num-lungs {
      max-width: 72px;
      padding: 5px 0 8px 0;
    }

    .big-num-lungs-content {
      max-width: 216px;
      padding: 0px 0 0 7px;
    }

    .big-num-lungs-content p {
      font-size: 18px;
      line-height: 24px;
    }

    .big-num-circle-tab-two-right-top {
      display: flex;
      gap: 21px;
    }

    .big-num-lama-laba {
      max-width: 91px;
      border-radius: 45px;
      height: 91px;
      width: 91px;
    }

    .big-num-lama-laba p {
      font-size: 81px;
      line-height: normal;
    }

    .big-num-groups {
      max-width: 248px;
      padding: 0 0 0 8px;
    }

    .big-num-groups-icon {
      margin: 0px 0 0 0;
    }

    .big-num-groups-content {
      max-width: 220px;
    }

    .big-num-circle-tab-two-right-bottom {
      display: flex;
      gap: 21px;
    }

    .big-num-ics-laba {
      max-width: 91px;
      border-radius: 45px;
      height: 91px;
      width: 91px;
    }

    .big-num-ics-laba p {
      font-size: 81px;
      line-height: normal;
    }

    .big-num-groups-ics-laba {
      max-width: 230px;
      padding: 0 0 0 8px;
    }

    .big-num-groups-ics-laba-content {
      max-width: 220px;
    }

    .big-num-circle-border-line {
      margin-top: 21px;
      margin-bottom: 24px;
    }

    .big-num-circle-border-bottom {
      content: "";
      display: block;
      width: 100%;
      height: 2px;
      margin-top: 19px;
      border-radius: 16px;
      background: #E8EAE8;
      max-width: 373px;
    }

    /****Efficacy Tab-2 big-num-circle Css end here****/
    /****Efficacy Tab-2 event-based-ntt Css start here****/
    .event-based-ntt-tab-two-main {
      padding: 0 0 78px 0;
    }

    .event-based-ntt-tab-two-inner {
      margin: 0 auto;
    }

    .event-based-ntt-content {
      padding: 16px 16px 16px 24px;
    }

    .event-based-ntt-content p {
      font-size: 20px;
      line-height: 26px;
    }

    /****Efficacy Tab-2 event-based-ntt Css ends here****/

    /****Efficacy Tab-2 Ethos design Css start here****/
    .ethos-design-tab-two-main {
      padding: 0 0 34px 0;
    }

    .ethos-design-content p {
      font-size: 24px;
      line-height: normal;
    }

    .ethos-design-content p::after {
      margin-top: 12px;
      margin-bottom: 38px;
    }

    /****Efficacy Tab-2 Ethos design Css end here****/

    /****Efficacy Tab-2 Patient-population Css start here****/
    .patient-population-tab-two-main {
      padding: 0px 0 50px 0;
    }

    .patient-population-content {
      padding: 0 5px;
    }

    /****Efficacy Tab-2 Patient-population Css end here****/

    /****Efficacy Tab-2 Patients-footnote Css start here****/
    .patients-footnote-tab-two-main {
      padding: 0 0 34px 0;
    }

    .patients-footnote-content {
      padding: 14px 20px;
    }

    /****Efficacy Tab-2 Patients-footnote Css end here****/

    /****Efficacy Tab-2 Reference Css start here****/
    #copd-clinical-trials-data #effi-word-break {
      word-break: break-all;
      font-family: 'Avenir-Book';
      font-size: 14px;
      line-height: 20px;
      color: #373A36;
      padding: 0px;
      position: relative;
      font-weight: 400;
    }

    #copd-clinical-trials-data .sample {
      padding: 36px 0 52px 0;
    }

    /****Efficacy Tab-2 Reference Css end here****/

    /*new update section tab2 starts here */

    /*new update section tab2 ends here */
    .treated-head p {
      font-size: 24px;
      line-height: 32px;
    }

    .treated-head h2 {
      font-size: 24px;
      line-height: 32px;
    }

    .prevemt {
      display: block;
      text-align: center;
    }

    .prevemt-treated-in h5 {
      font-size: 18px;
      line-height: 22px;
      margin: 0 0 17px 0;
    }

    .prevemt-content {
      display: block;
    }

    .prevemt-content>p {
      max-width: 216px;
      padding: 0;
      font-size: 16px;
      line-height: 24px;
      margin: 0 auto;
      text-align: center;
      padding: 15px 0 0 0;
    }

    .treated-head {
      padding: 0 0 35px 0;
    }

    .prevemt-treated-block1 .prevemt-content p {
      max-width: 100%;
    }

    .prevemt-treated-in figure {
      margin: 20px 0 20px 0;
    }

    .prevemt-content>span {
      margin: 0 auto;
      width: 75px;
      height: 75px;
      font-size: 65px;
      padding: 7px 0 0 0;
    }

    .additional-prevemt p {
      font-size: 16px;
      line-height: 24px;
      text-align: center;
    }

    .additional-note p {
      font-size: 14px;
      line-height: 20px;
      text-align: center;
    }

    .prevemt-treated-in figure {
      max-width: 150px;
      margin: 30px auto;
    }

    .treated-block {
      padding: 0 0 35px 0;
    }
  }

  /****Efficacy Tab-2 Mobile CSS ends here****/

  @media screen and (max-width: 335px) {

    /****Efficacy Tab-1 Mobile CSS starts here****/
    #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab,
    #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab,
    #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab {
      font-size: 14px;
    }

    .efficacy-banner-content h1 {
      font-size: 24px;
      line-height: 30px;
      max-width: 150px;
      padding: 10px 0 0 0;
    }

    /****Efficacy Tab-1 Mobile CSS ends here****/
  }



  /* US-102140 Breztri HCP Phase 1 NPP Website & Phase 2 Efficacy Updates style starts here*/


  .efficacy-banner-content a {
    padding: 0 0 4px 0;
    margin: 0 0 18px 0;
    border: none;
    border-bottom: 2px solid #2CD5C4;
    border-radius: 0;
    font-size: 18px;
    line-height: 24px;
     font-family: 'Avenir-Heavy';   font-weight: 800;
    color: #FFFFFF; 
  }

  .efficacy-banner-content a::after {
    content: '';
    position: absolute;
    left: 0;
    bottom: 0;
    width: 100%;
    height: 10px;
    background: linear-gradient(90deg, rgba(195, 137, 0, 1) 0%, rgba(240, 178, 36, 1) 50%);
  }

  .efficacy-banner-content h1 {
    font-family: 'Avenir-Black';
    color: #FFFFFF;
  }

  .efficacy-banner-in {
    padding: 60px 0 30px 0;
  }

  #copd-clinical-trials-data #tabs-block ol.cmp-tabs__tablist,
  #copd-clinical-trials-data #tabs-block ol.cmp-tabs__tablist,
  #copd-clinical-trials-data #tabs-block ol.cmp-tabs__tablist {
    max-width: 1093px;
  }

  #copd-clinical-trials-data #tabs-block .cmp-tabs__tablist li:nth-child(3),
  #copd-clinical-trials-data #tabs-block .cmp-tabs__tablist li:nth-child(3),
  #copd-clinical-trials-data #tabs-block .cmp-tabs__tablist li:nth-child(3) {
    padding-top: 20px;
    padding-bottom: 20px;
  }

  .clinical-data-container {
    max-width: 1025px;
    padding: 0 15px;
    margin: 0 auto;
  }

  .exlpore-head-main {
    padding: 60px 0 30px 0;
  }

  .exlpore-head h2 {
    font-family: 'Avenir-Heavy';
    font-size: 32px;
    line-height: 38px;
    color: #121312;
    font-weight: 800;
    text-align: center;
  }

  .etohs-main {
    background-color: #F5F5F5;
    border-radius: 16px;
    margin-bottom: 65px;
  }

  .etohs-content {
    padding: 38px 48px 38px 48px;
  }

  .etohs-content h3 {
    font-family: 'Avenir-Heavy';
    font-size: 20px;
    line-height: 24px;
    font-weight: 800;
    color: #121312;
    margin: 0 0 10px 0;
  }

  .etohs-content h3 sup {
   font-family: 'Avenir-Roman';
    font-weight: normal;
  }

  .etohs-content p {
    font-size: 16px;
    line-height: 20px;
    font-family: 'Avenir-Book';
    color: #373A36;
  }

  .etohs-content p sup {
    color: #373A36;
  }

  #clinical-data-accordion {
    max-width: 1025px;
    padding: 0 15px;
    margin: 0 auto;
  }

  #clinical-data-accordion .cmp-accordion__button {
    padding: 25px 0 0 0;
  }

  #clinical-data-accordion .cmp-accordion__icon::before {
    content: '\f067';
    color: #121212;
    background: #F0B323;
    border-radius: 8px;
    height: 28px;
    width: 28px;
    display: block;
    text-align: center;
    font-family: 'icomoon' !important;
    line-height: 30px;
  }

  #clinical-data-accordion .cmp-accordion__icon:hover:before {
    background: #F5CC6C;
  }

  #clinical-data-accordion .cmp-accordion__button--expanded .cmp-accordion__icon::before {
    content: '\f068';
    font-family: 'icomoon' !important;
  }

  #clinical-data-accordion .cmp-accordion__panel {
    padding: 0;
  }

  #clinical-data-accordion .cmp-accordion__header {
    padding: 0 0 25px 0;
  }

  #clinical-data-accordion .cmp-accordion__item {
    border-top: #E8EAE8 2px solid;
    padding: 0;
  }

  #clinical-data-accordion h5.accordion_title {
    padding-left: 0;
    font-size: 32px;
    line-height: 38px;
    font-weight: 500;
    font-family: 'Avenir-Medium';
    color: #373A36; text-transform: uppercase;  
  }

  #clinical-data-accordion h5.accordion_title sup {
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
  }

  #clinical-data-accordion .cmp-accordion__icon {
    padding: 0 1px;
  }

  #clinical-data-accordion #primary-accordian {
    margin: 60px 0 0 0;
  }

  #clinical-data-accordion #primary-accordian .cmp-accordion__item {
    border-top: none;
  }

  .treated-block {
    padding: 0;
  }

  .treated-content {
    padding: 0;
  }

  .event-treat {
    padding: 0 0 37px 0;
  }

  .event-treat h4 {
    font-family: 'Avenir-Heavy';
    font-size: 32px;
    line-height: 38px;
    color: #373A36;
    font-weight: 800;
  }

  .event-treat h4 sup {
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
  }

  .event-view {
    padding: 0 0 33px 0;
  }

  .event-view figure {
    margin: 0;
    text-align: center;
  }

  .event-view figure img {
    margin: 0 auto;
  }

  .additional-severe {
    padding: 0 0 37px 0;
  }

  .additional-severe h5 {
    font-family: 'Avenir-Heavy';
    font-size: 28px;
    line-height: 34px;
    color: #373A36;
    font-weight: 800;
    text-align: center;
  }

  .additional-severe h5 sup {
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
  }

  .additional-exacerbation {
    padding: 0 0 15px 0;
    border-bottom: #2CD5C4 2px solid;
  }

  .additional-exacerbation p {
    font-size: 24px;
    line-height: 32px;
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
    padding-right: 26px;
  }

  .additional-exacerbation p span {
    font-family: 'Avenir-Heavy';
    font-weight: 800;
  }

  .event-nnt {
    padding: 20px 46px 10px 0;
  }

  .event-nnt p {
    font-size: 16px;
    line-height: 24px;
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
  }

  .moderate-severe {
    padding: 0 0 40px 0;
  }

  .moderate-severe p {
    font-size: 14px;
    line-height: 20px;
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
  }

  .moderate-severe p.moderate-terms {
    position: relative;
    padding-left: 7px;
  }

  .moderate-severe p span.special-icon {
    position: absolute;
    left: 0;
  }

  .ethos-design-block {
    padding: 0;
  }

  .ethos-design {
    background-color: #F5F5F5;
    padding: 32px 39px 32px 48px;
    border-radius: 16px;
    margin-top: 20px;
  }

  .ethos-design h3 {
    font-family: 'Avenir-Heavy';
    font-size: 24px;
    line-height: 32px;
    color: #121312;
    font-weight: 800;
    margin: 0 0 10px 0;
  }

  .ethos-design h3 sup { font-family: 'Avenir-Book'; font-weight: 400;
    color: #121312; 
  }

  .ethos-design p {
    font-size: 16px;
    line-height: 24px;
    font-family: 'Avenir-Book';
    color: #121312;
    font-weight: normal;
  }

  .pulmonary-chronic {
    padding: 20px 0 85px 0;
  }

  .pulmonary-chronic p {
    font-size: 14px;
    line-height: 24px;
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
  }

  .mortality-content {
    padding: 50px 0 0 0;
  }

  .mortality-head {
    padding: 0 0 55px 0;
  }

  .mortality-head h3 {
    font-family: 'Avenir-Heavy';
    font-size: 32px;
    line-height: 38px;
    color: #121312;
    font-weight: 800;
    margin: 0 0 10px 0;
    text-align: center;
  }

  .mortality-head p {
    font-size: 32px;
    line-height: 38px;
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
    text-align: center;
  }

  .mortality-view {
    padding: 0 0 30px 0;
  }

  .mortality-view figure {
    margin: 0;
    text-align: center;
  }

  .mortality-view figure img {
    margin: 0 auto;
  }

  .mortality-population {
    padding: 0 0 44px 0;
    max-width: 920px;
  }

  .mortality-population p {
    font-family: 'Avenir-Medium';
    font-size: 16px;
    line-height: 24px;
    color: #373A36;
    font-weight: 800;
    padding: 0 0 18px 0;
  }

  .mortality-incidence {
    background-color: #F5F5F5;
    border-radius: 8px;
    padding: 14px 32px;
  }

  .mortality-incidence p {
    max-width: 931px;
    font-family: 'Gotham-Book';
    font-size: 14px;
    line-height: 20px;
    color: #121312;
    font-weight: 400;
  }

  a.reference_link {
    color: #373A36;
  }

  .clinical-kronos {
    background-color: #F5F5F5;
    padding: 33px 48px;
    border-radius: 16px;
    margin-top: 30px;
    margin-bottom: 35px;
  }

  .clinical-kronos-list {
    padding: 0;
  }

  .clinical-kronos-list h3 {
    font-family: 'Avenir-Heavy';
    font-size: 20px;
    line-height: 24px;
    color: #121312;
    font-weight: 800;
    margin:0 0 10px 0;
  }

  .clinical-kronos-list h3 sup {
    font-family: 'Avenir-Book';
    color: #121312;
    font-weight: normal;
    margin: 0 0 10px 0;
  }

  .clinical-kronos-list p {
    font-size: 16px;
    line-height: 24px;
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
  }

  .clinical-kronos-list-first {
    margin: 0 0 22px 0;
  }

  .study-data {
    padding: 10px 0 30px 0;
  }

  .study-data h3 {
    font-family: 'Avenir-Heavy';
    font-size: 20px;
    line-height: 24px;
    color: #373A36;
    font-weight: 800;
     
  }

  .study-data h3 sup {
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
  }

  .study-data p {
    font-size: 16px;
    line-height: 20px;
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
  }

  .study-data p span.break-word {
    display: inline-block;
  }

  .study-limitations {
    padding: 0 0 40px 0;
  }

  .study-limitations h3 {
    font-family: 'Avenir-Heavy';
    font-size: 20px;
    line-height: 24px;
    color: #373A36;
    font-weight: 800;
    margin: 0 0 5px 0;
  }

  .study-limitations h3 sup {
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
  }

  .retrospective .study-limitations ul {
    margin: 0;
    padding: 0;
    max-width: 910px;
  }

  .study-limitations ul li {
    position: relative;
    padding: 0 0 0 15px;
    margin: 0 0 5px 0;
  }

  .study-limitations ul li::before {
    content: '';
    position: absolute;
    left: 0;
    top: 9px;
    background-color: #F0B323;
    width: 6px;
    height: 6px;
    border-radius: 100%;
  }

  .study-limitations ul li p {
    font-size: 16px;
    line-height: 24px;
    font-family: 'Avenir-Book';
    color: #121312;
  }

  .data-annualized-graph {
    padding: 10px 0 10px 0; max-width: 840px;
  }

  .data-annualized-view figure {
    margin: 0; 
  }

  .data-annualized-view figure img {
    margin: 0 auto;
  }

  .data-annualized-head {
    padding: 0 0 15px 0;  
  }

  .data-annualized-head h3 {
    padding: 0;
    font-size: 25px;
    line-height: 30px;
    font-weight: 800;
    font-family: 'Avenir-Heavy';
    color: #373A36;

  }

  .data-annualized-head h3 span {
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
  }

  .data-annualized-head h3 sup {
    font-family: 'Avenir-Book';
    font-weight: normal;
  }
 
  span.break-word {
    word-break: break-all;
  }

  .strange {
    padding: 0 24px 5px 0;
  }

  .strange p {
    font-size: 14px;
    line-height: 20px;
    font-family: 'Avenir-Book';
    color: #373A36 !important;
  }

  .strange p i.italic-style {
    font-family: 'Avenir-BookOblique';
  }

  .strange p span a {
    color: #373A36 !important;
  }

  .moderate-severe {
    padding: 0 0 40px 0;
  }

  .retrospective-note p {
    font-size: 14px;
    line-height: 20px;
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
    margin: 0 0 5px 0;
  }

  .retrospective-note p.retrospective-terms {
    position: relative;
    padding-left: 7px;
  }

  .retrospective-note p span.special-icon {
    position: absolute;
    left: 0;
  }

  .retrospective {
    padding: 0 0 30px 0;
  }

  .fri-trelegy {
    margin-top: 10px; 
  }

  .fri-trelegy h3 {
    font-family: 'Avenir-Heavy';
    font-size: 25px;
    line-height: 32px;
    color: #121312;
    font-weight: 800;
    margin: 0 0 6px 0;
  }

  .fri-trelegy h3 sup {
    font-family: 'Avenir-Book';
    color: #121312;
    font-weight: normal;
  }

  .fri-trelegy h3 span {
    font-family: 'Avenir-HeavyOblique';
  }

  .fri-trelegy p {
    font-size: 16px;
    line-height: 24px;
    font-family: 'Avenir-Book';
    color: #121312;
    font-weight: normal;
  }

  .fri-trelegy p sup {
    font-family: 'Avenir-Book';
    color: #121312;
    font-weight: normal;
  }

  .fri-trelegy p span {
    font-family: 'Avenir-BookOblique';
  }

  .fri-trelegy p{
    font-weight: 800;
    font-family: 'Avenir-Heavy';
  }

  .fri-trelegy p span{
    font-family: 'Avenir-HeavyOblique';
  }

  .study-data-lung p span {
    font-family: 'Avenir-BookOblique';
  }

  .study-data-lung {
    padding: 10px 18px 30px 0;
  }

  .study-data-lung p {
     line-height: 24px;
  }
  .study-limitations-lung p span {
    font-family: 'Avenir-BookOblique';
  }
 
  .data-lung-head {
    padding: 0 10px 27px 40px;
  } 

  .data-lung-head h3 sup {
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
  }

  .lung-graphic-note {
    padding: 0;
  }

  .lung-graphic-note p {
    font-size: 14px;
    line-height: 20px;
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
  }

  .lung-graphic-note p.lung-graphic-terms {
    position: relative;
    padding-left: 6px;
    padding-top: 4px;
  }

  .lung-graphic-note p span.special-icon {
    position: absolute;
    left: 0;
  }

  .lung-chronic {
    padding: 40px 0 0 0;
  }

  .lung-chronic p {
    font-size: 14px;
    line-height: 20px;
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
  }

  .study-limitations-lung {
    padding: 0 0 30px 0;
  }

  .data-annualized-view-first {
    margin: 0 0 20px 0;
  }

  .therapies-head-main {
    padding: 56px 0 32px 0;
  }

  .therapies-head h2 {
     font-family: 'Avenir-Black';
    font-size: 39px;
    line-height: 42px;
    color: #373A36;
    font-weight: 900;
    text-align: center;
    text-transform: uppercase;
    max-width: 710px;
    margin: 0 auto;
  }
 
  .kronos-main {
    background-color: #F5F5F5;
    border-radius: 16px;
    margin-bottom: 40px;
  }

  .kronos-data {
    padding: 38px 46px;
    max-width: 969px;
  }

  .kronos-data h3 {
    font-family: 'Avenir-Heavy';
    font-size: 20px;
    line-height: 24px;
    font-weight: 800;
    color: #121312;
    margin: 0 0 10px 0;
  }

  .kronos-data h3 sup {
    font-family: 'Avenir-Book';
    font-weight: normal;
  }

  .kronos-data p {
    font-size: 18px;
    line-height: 24px;
    font-family: 'Avenir-Book';
    color: #121312;
  }

  .kronos-data p sup {
    color: #373A36;
  }

  .reduction-data-note {
    padding: 0 0 9px 0;
  }

  .reduction-data-note p {
    font-size: 18px;
    line-height: 24px;
    font-family: 'Avenir-Book';
    color: #373A36;
  }

  .reduction-data-head h3 {
    padding: 0;
    font-size: 32px;
    line-height: 38px;
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
    text-transform: uppercase;
    max-width: 920px;
  }

  .reduction-data-head h3 span {
    font-weight: 800;
    font-family: 'Avenir-Heavy';
    color: #373A36;

  }

  .reduction-data-head h3 sup {
    font-family: 'Avenir-Book';
    font-weight: normal;
  }

  .reduction-ratio-block {
    padding: 60px 0 30px 0;
    display: flex;
    align-items: center;
    justify-content: space-around;
  }

  .reduction-ratio-view {
    padding: 0;
    width: 50%;
  }

  .reduction-ratio-view figure {
    margin: 0;
    text-align: center;
  }

  .reduction-ratio-view figure img {
    margin: 0 auto;
    max-width: 285px;
  }

  .reduction-ratio-content {
    width: 50%;
    padding: 0 0 0 10px;
  }

  .reduction-ratio-content p {
    font-size: 16px;
    line-height: 24px;
    font-family: 'Avenir-Book';
    color: #121312;
    font-weight: normal;
  }

  p.rate-percentage {
    font-family: 'Avenir-Heavy';
    font-weight: 800;
    color: #121312;
  }

  .reduction-ratio-content h3 {
    padding: 0;
    font-size: 24px;
    line-height: 32px;
    font-family: 'Avenir-Heavy';
    font-weight: 800;
    color: #121312;
    margin-top: 22px;
    margin-bottom: 2px;
  }

  .moderate-data-note {
    padding: 12px 0 10px 0;
    max-width: 412px;
  }



  .moderate-data-note p span {
    font-family: 'Avenir-Heavy';
    font-weight: 800;
    color: #121312;
  }

  .kronos-study-main {
    background-color: #F5F5F5;
    margin-bottom: 40px;
    margin-top: 20px;
    border-radius: 16px; margin-top: 40px;
  }

  .kronos-study-content {
    padding: 35px 46px;
  }

  .kronos-study-content h3 {
    font-family: 'Avenir-Heavy';
    font-size: 20px;
    line-height: 24px;
    font-weight: 900;
    color: #121312;
    margin: 0 0 10px 0;
  }

  .kronos-study-content h3 sup {
    font-family: 'Avenir-Book';
    font-weight: normal;
  }

  .kronos-study-content p {
    font-size: 16px;
    line-height: 20px;
    font-family: 'Avenir-Book';
    color: #121312;
  }

  .kronos-study-content p sup {
    color: #373A36;
  }

  .kronos-footnote {
    padding: 0 0 8px 0;
  }

  .kronos-footnote p {
    font-size: 13px;
    line-height: 16px;
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
    margin: 0 0 4px 0;
  }

  .kronos-footnote p.kronos-terms {
    position: relative;
    padding-left: 6px;
  }

  .kronos-footnote p span.special-icon {
    position: absolute;
    left: 0;
  }

  .muscarinic p {
    font-size: 13px;
    line-height: 16px;
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
  }
  .aerosphere { padding: 0 30px;}
   .aerosphere p {
    font-size: 13px;
    line-height: 16px;
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal; 
  }
  .aerosphere p.aero-term { position: relative; padding-left: 6px;}
    
  .aerosphere p span.special-icon {
    position: absolute;
    left: 0;
    }
    
    .clinical-button-tab1 .sample-button-block {
        padding: 20px 0 60px 0;
    }

  span.ref-tell {
    cursor: default;
    pointer-events: none;
  }

  .reference-content ul li p span.ref-tell {
    cursor: default;
    pointer-events: none;
    position: static;
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
  }

  .reference-content ul li p span.ref-tell a {
    color: #373A36;
  }

  .sample-button-order-data1 a {
    padding: 18px 36px 18px 38px;
  }

  .sample-button-order-data1 a span {
    padding-right: 27px;
  }

  .sample-button-order-data1 a span::after {
    background: url(/content/dam/intelligentcontent/brands/breztri-hcp/us/en/images/phase1/global/vector.svg);
    display: inline-block;
    width: 8px;
    height: 14px;
    top: 8px;
    right: 0;
  }

  .clinical-button-tab3.sample-button-block {
    padding: 70px 0 70px 0;
  }

  /*  US-106667 - BREZTRI HCP Website January 2026 Update Style starts here */
  #copd-clinical-trials-data #resources-tabs::before,
  #copd-clinical-trials-data #resources-tabs::before {
    height: 50%;
  }

  #copd-clinical-trials-data #resources-tabs::before {
    height: 60%;
  }

  #copd-clinical-trials-data #resources-tabs::after,
  #copd-clinical-trials-data #resources-tabs::after {
    height: 50%;
  }

  #copd-clinical-trials-data #resources-tabs::after {
    height: 60%;
  }

  .efficacy-banner-main {
    background-image: url(/content/dam/intelligentcontent/brands/breztri-hcp/us/en/images/phase2/desktop/safety/safety_bg.jpg);
    background-size: cover;
    background-repeat: no-repeat;
    position: relative;
    min-height: 270px;
  }

  .etohs-main {
    background-color: #FFFFFF;
    margin-top: 50px;
    box-shadow: 0px 4px 25px 0px #00000017;
  }

  .etohs-content p {
    font-size: 16px;
    line-height: 24px;
  }

  .exacerbation-data-container {
    max-width: 1025px;
    padding: 0 15px;
    margin: 0 auto;
  }

  .exacerbation-mortality-head {
    padding: 0;
  }

  .exacerbation-mortality-head h2 {
   font-family: 'Avenir-Black';
    font-size: 39px;
    line-height: 44px;
    color: #373A36;
    font-weight: 900;
    padding: 0 0 28px 0; text-transform: uppercase;  
  }

  .exacerbation-mortality-head p {
   font-family: 'Avenir-Light';
    font-size: 20px;
    line-height: 24px;
    color: #373A36;
    font-weight: 300; 
    text-transform: uppercase; text-align: center; padding: 0 0 5px 0;
  }

  .exacerbation-mortality-head h3 {
   font-family: 'Avenir-Medium';
    font-size: 31px;
    line-height: 34px;
    color: #373A36;
      font-weight: 500;
    text-transform: uppercase; text-align: center;
  }

   
  .hazard-ratio {
    padding: 40px 0 0 0;
  }

  .hazard-ratio figure {
    margin: 0; text-align: center;
  }

  .hazard-ratio p {
    font-size: 12px;
    line-height: 14px;
    color: #42454A;
    font-family: 'Avenir-Roman';
    font-weight: 400;
    text-align: center;
    padding: 22px 0 50px 0;
  }

  .mortality-ratio-content {
    padding: 0 20px 0 0;
  }

  .mortality-ratio-content p {
    font-family: 'Avenir-Heavy';
    font-size: 16px;
    line-height: 20px;
    color: #373A36;
    font-weight: 800;
    padding: 0 0 18px 0;
  }

  .exacerbation-severe {
    padding: 0;
  }

  .exacerbation-severe p {
    padding: 0;
    font-family: 'Avenir-Book';
    font-size: 13px;
    line-height: 16px;
    color: #373A36;
  }

  .ethos-design {
    box-shadow: 0px 4px 25px 0px #00000017;
    background-color: #FFFFFF;
    margin-top: 35px;
  }

  .exacerbation-budesonide {
    padding: 40px 5px 10px 10px; 
    border-radius: 16px; 
  }

  .exacerbation-budesonide p {
    font-size: 13px;
    line-height: 16px;
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal; 
  }
  .exacerbation-daily {
    padding: 0 5px 0 5px;  
    margin-top: 40px;
  }
   .exacerbation-daily p {  font-size: 13px;
    line-height: 16px;
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;}
 .exacerbation-daily p.exacerbation-daily-terms { position: relative; padding-left: 6px;} 
 .exacerbation-daily p.exacerbation-daily-terms span.special-icon {
    position: absolute;
    left: 0;
    }
  .exacerbation-budesonide p {
    font-size: 13px;
    line-height: 16px;
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal; 
  }
  .clinical-kronos {
    background-color: #FFFFFF;
    box-shadow: 0px 4px 25px 0px #00000017;
  } 

  .data-annualized-head p {
    font-family: 'Avenir-Medium';
    font-size: 24px;
    line-height: 34px;
    color: #373A36;
    font-weight: 500;
    padding-top: 5px;
  }

  .data-lung-head {
    padding: 0 0 30px 0;
  }

  .data-lung-head h3 {
    font-size: 25px;
    line-height: 28px;
    font-family: 'Avenir-Heavy';
    color: #373A36;
    font-weight: 800;
    text-transform: uppercase;
    padding: 0 90px 21px 0;
    
  }

  .data-lung-head h3 sup {
    font-family: 'Avenir-Book';
    color: #373A36;
  } 
   

  .data-lung-head h5 sup {
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: 400;
  }

  .data-lung-head p {
    font-family: 'Avenir-Heavy';
    font-size: 22px;
    line-height: 30px;
    color: #121312;
    font-weight: 800;
    padding: 0; max-width: 900px;
  }

  .strange {
    padding: 5px 0 5px 0;
  }

  .lung-lama {
    padding: 20px 0 15px 0;
  }

  .lung-lama p {
    font-family: 'Avenir-Black';
    font-size: 17px;
    line-height: 24px;
    color: #373A36;
    font-weight: 800;
  }

  .lung-chronic {
    padding:20px 0 0 0;
  }

  .therapies-head-main {
    padding: 45px 0 40px 0;
  }

  .kronos-main {
    background-color: #ffffff;
    box-shadow: 0px 4px 25px 0px #00000017; 
    margin-bottom: 55px;
  }

  .kronos-data p {
    font-size: 16px;
    line-height: 24px;
  }

  .kronos-data {
    padding: 38px 45px;
    max-width: 980px;
  }

  .reduction-data-head {
    padding: 0 0 49px 0;
  }

  .reduction-data-head h3 {
    font-family: 'Avenir-Black';
    font-size: 32px;
    line-height: 38px;
    color: #373A36;
    max-width: 930px;
  } 

  .breztri-popup-veiw {
    position: relative;
    
  }

  a.popup-therapy {
    position: absolute;
    top: -30px;
    right: -20px;
  }

  .breztri-popup-severe {
    padding: 0;
  }

  .breztri-popup-severe figure {
    padding: 0;
    margin: 0;
  }

  .breztri-popup-severe figure img {
    border-radius: 30px;
    box-shadow: rgba(0, 0, 0, 0.2) 0px 18px 50px -23px;
    width: 100%;
  }

  .breztri-therapy-veiw {
    position: relative;
  }
 
  .therapy-reduction {
    padding: 18px 0 20px 0;
    text-align: center;
  }

  .therapy-reduction h4 {
    font-size: 24px;
    line-height: 32px;
    font-family: 'Avenir-Heavy';
    color: #121312;
    font-weight: 800;
    padding: 0 0 8px 0;
  }

  .therapy-reduction p.therapy-rate {
    position: relative;
    font-size: 16px;
    line-height: 20px;
    font-family: 'Avenir-Book';
    color: #121312;
    font-weight: normal;
    margin: 0 0 10px 0;
    padding: 0 0 18px 0;
  }

  .therapy-reduction p.therapy-rate::after {
    content: '';
    position: absolute;
    left: 0;
    right: 0;
    max-width: 337px;
    height: 2px;
    background-color: #2CD5C4;
    margin: 0 auto;
    bottom: 0;
  }

  .therapy-reduction p.therapy-estimate {
    position: relative;
    font-size: 16px;
    line-height: 20px;
    font-family: 'Avenir-Roman';
    color: #121312;
    font-weight: normal;
    max-width: 310px;
    margin: 0 auto;
  }

  .therapy-reduction p.therapy-estimate span {
    font-weight: 800;
  }

  .kronos-footnote {
    padding:50px 0 30px 0;
  }

  .kronos-study-main {
    background-color: #FFFFFF;
    box-shadow: 0px 4px 25px 0px #00000017;
  }

  .muscarinic {
    padding: 8px 30px 20px 30px;
    background-color: #FFFFFF;
  
  }

  /* model popup starts here*/

  body .popup-clinical.modal.cmp-modal__modalbox .modal__closeIcon {
    z-index: 99;
  }

  span.modal__closeIcon {
    pointer-events: auto;
  }

  body.modal-enabled {
    overflow-y: hidden;
    width: 100%;
    height: 100vh;
    position: fixed;
    z-index: 999999;
  }

  body .popup-clinical.modal.cmp-modal--defaultStyle.modal--visible {
    padding-top: 2vh;
    padding-bottom: 10vh;
  }

  body .popup-clinical.modal.cmp-modal__modalbox {
    position: fixed;
    top: 0;
    right: 0;
    bottom: 0;
    left: 0;
    z-index: 1000;
    background: rgba(0, 0, 0, 0.7);
    backdrop-filter: none;
    -webkit-backdrop-filter: none;
    cursor: auto;
  }

  body .popup-clinical.modal.cmp-modal__modalbox .modal__close {
    color: #455E89;
    display: flex;
    flex-direction: row-reverse;
    justify-content: end;
    position: relative;
    width: 100%;
    cursor: auto;
    top: 0;
    left: 0;
    margin: 0 auto;
    max-width: 1172px;
    border: none;
    background: transparent;
    z-index: 999;
    padding: 0;
    padding-right: 0;
    height: 77px;
    outline: none;
    pointer-events: none;
    margin-bottom: 0;
  }


  body .popup-clinical.modal.cmp-modal__modalbox .modal__close svg {
    background-image: url(/content/dam/intelligentcontent/brands/breztri-hcp/us/en/images/phase2/desktop/efficacy/close_icon.svg);
    background-repeat: no-repeat;
    padding: 10px;
    border-radius: 100%;
    width: 86px;
    height: 86px;
    border: 0px solid #fff;
    color: #fff;
    background-size: 86px;
  }

  body .popup-clinical.modal.cmp-modal__modalbox .modal-box {
    max-width: 1172px;
    margin: 0 auto;
    background: #ffffff;
    border-radius: 16px;
    padding: 0;
    position: relative;
    top: 30px;
    animation: none;
    width: 100%;
  }

  body .popup-clinical.cmp-modal--defaultStyle .modal__close svg * {
    fill: transparent;
  }

  body .popup-clinical.modal.cmp-modal__modalbox .modal-box .modal-box__content {
    padding: 0;
  }

  body .popup-clinical.cmp-modal__content {
    padding: 0 25px;
  }

  body .popup-clinical.cmp-video__player {
    padding: 0 15px;
  }

  body .popup-clinical.modal.cmp-modal__modalbox .modal__close .modal__closeLabel {
    display: none;
  }

  /* model popup ends here*/


  .clinical-popup-container {
    max-width: 1019px;
    padding: 0 10px;
    margin: 0 auto;
  }

  .clinical-popup-head h2 {
    font-family: 'Avenir-Black';
    font-size: 32px;
    line-height: 38px;
    color: #373A36;
    font-weight: 900;
    text-transform: uppercase;
    margin: 0 0 10px 0;
  }

  .clinical-popup-head h2 sup {
    font-family: 'Avenir-Book';
    font-weight: normal;
  }

  .clinical-popup-head p {
    font-family: 'Avenir-Medium';
    font-size: 22px;
    line-height: 28px;
    color: #121312;
    font-weight: 500;
  }

  .clinical-popup-view {
    padding: 0;
  }

  .clinical-popup-view figure {
    padding: 0;
    margin: 0;
  }

  .clinical-popup-view figure img {
    padding: 0;
    margin: 0 auto;
  }

  .clinical-popup-head {
    padding: 0 0 40px 0;
  }

  .clinical-data-popup {
    padding: 0 0 50px 0;
  }

  .clinical-popup-head p span {
    font-family: 'Avenir-Black';
    font-weight: 900;
  }

  .clinical-popup-two .clinical-data-popup {
    padding: 0 0 40px 0;
  }

  .clinical-popup-note {
    padding: 20px 0 0 0;
  }

  .clinical-popup-note p {
    font-size: 14px;
    line-height: 20px;
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
    padding: 0 0 10px 0;
  }

  .clinical-popup-note p span {
    font-family: 'Avenir-Heavy';
    font-weight: 800; font-size: 16px; line-height: 20px;
  }
 .demonstrate-main { padding: 22px 0 45px 0;}
.demonstrate-head { padding: 0;}
.demonstrate-head h3 {
    font-family: 'Avenir-Black';
    font-size: 39px;
    line-height: 42px;
    color: #373A36;
    font-weight: 900;
    text-align: center;
    text-transform: uppercase; 
}
.demonstrate-head h3 sup { font-family: 'Avenir-Roman'; font-weight: normal;}
span.breat { color: #BF890D;}
.clinical-popup-two .clinical-popup-view figure { text-align: center; }
.clinical-button-tab2 .sample-button-block { padding: 40px 0 70px 0;} 
.efficacy-drug h3 { 
    font-family: 'Avenir-Heavy';
    font-size: 25px;
    line-height: 28px;
    color: #121312;
    font-weight: 800; 
    text-transform: uppercase; margin:23px 0 15px 0; }
.efficacy-drug h3 sup {  font-family: 'Avenir-Roman'; font-weight: normal; }
.efficacy-drug p {
  font-family: 'Avenir-Heavy';
    font-size: 18px;
    line-height: 22px;
    color: #121312;
    font-weight: 800; 
    padding-right: 20px;
}
.data-annualized-content { padding: 0 0 3px 35px; }
.data-annualized-content p { 
    font-size: 16px;
    line-height: 20px;
    font-family: 'Avenir-Book'; color: #121312;}
.deposition { padding: 15px 0 20px 0;}
.deposition p { font-family: 'Avenir-Medium'; font-size: 16px;
    line-height: 20px;
    color: #121312; 
    font-weight: 500;
  }
.dimensional { padding:20px 0 0 0;}
.dimensional p { 
    font-size: 13px;
    line-height: 16px;
    font-family: 'Avenir-Book';
    color:#373A36;
    font-weight: normal;}
  .dimensional p span.glycopy { word-break: break-all; }
.ellipta { padding: 17px 0 0 0;}
.ellipta p {
    font-size: 13px;
    line-height: 16px;
    font-family: 'Avenir-Book';
    color: #373A36;
    font-weight: normal;
}
#copd-clinical-trials-data .reference-content ul li p b.ref-date a { font-family: 'Avenir-Book'; color: #373A36 !important; font-weight: 400; }
  /*  US-106667 - BREZTRI HCP Website January 2026 Update Style end here */

  @media screen and (max-width:1200px) {
    .additional-exacerbation p {
      padding-right: 0;
    }

    .event-nnt {
      padding: 20px 0px 10px 0;
    }
  }

  @media screen and (min-width: 991px) {

    #copd-clinical-trials-data #tabs-block ol.cmp-tabs__tablist,
    #copd-clinical-trials-data #tabs-block ol.cmp-tabs__tablist,
    #copd-clinical-trials-data #tabs-block ol.cmp-tabs__tablist {
      top: 84px;
    }

    #copd-clinical-trials-data #resources-tabs,
    #copd-clinical-trials-data #resources-tabs,
    #copd-clinical-trials-data #resources-tabs {
      position: relative;
      margin: 0;
      margin-top: 20px;
    }

    #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab,
    #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab,
    #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab {
      width: 32%;
      background: transparent;
      border: 1px solid #F0B323;
      text-align: center;
      color: #FFFFFF;
      border-radius: 50px;
      padding: 12px 5px 12px 5px;

    }

    #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab--active,
    #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab--active,
    #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab--active {
      background: #FFFFFF;
      color: #F5F5F5;
      border: 1px solid #2CD5C4;
      color: #121312;
    }

    .clinical-button-tab1 .sample-button-order,
    .clinical-button-tab2 .sample-button-order,
    .clinical-button-tab3 .sample-button-order {
      margin-right: 30px;
    }

    #tabs-block.sticky-tab ol.cmp-tabs__tablist {}

   /* #tabs-block.sticky-tab ol.cmp-tabs__tablist::before {
      background-color: #ddf6f7;
      width: 100%;
      height: 20px;
      bottom: 100%;
      content: '';
      left: 0;
      position: absolute;
    } */

    .clinical-button-tab3 .sample-button-block {
      padding: 80px 0 80px 0;
    }

    .fri-trelegy p {
      padding-right: 4px;
    }

    .clinical-popup-head h2 br {
      display: none;
    }
    .reference-content ul li p.budesonide-pad { padding-right: 24px; }
  }

  @media screen and (max-width: 991px) {
    .efficacy-banner-content h1 {
      font-size: 29px;
      line-height: 33px;
    }

    #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab,
    #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab,
    #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab {
      margin: 0 0 18px 0;
      padding: 10px 5px 10px 5px;
      box-shadow: rgba(0, 0, 0, 0.24) 0px 3px 8px;
      display: block;
      width: 100%;
      text-align: center;
      border-radius: 50px;
      background-color: #373A36;
      color: #FFF;
      border: 1px solid #F0B323;
    }

    #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab--active,
    #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab--active,
    #copd-clinical-trials-data #tabs-block li.cmp-tabs__tab--active {
      background: #FFFFFF;
      border: 1px solid #2CD5C4;
      color: #121312;
    }

    #copd-clinical-trials-data #tabs-block .cmp-tabs__tablist li:nth-child(3),
    #copd-clinical-trials-data #tabs-block .cmp-tabs__tablist li:nth-child(3),
    #copd-clinical-trials-data #tabs-block .cmp-tabs__tablist li:nth-child(3) {
      padding-top: 14px;
      padding-bottom: 14px;
    }
 
    a.reference_link {
      word-break: break-all;
    }

    a.reference_link-break-none {
      display: inline-block;
    }

    .efficacy-banner-in {
      padding: 50px 0 30px 4px;
    }

    #copd-clinical-trials-data .efficacy-banner-main,
    #copd-clinical-trials-data .efficacy-banner-main,
    #copd-clinical-trials-data .efficacy-banner-main {
      min-height: 260px;
    }

    .efficacy-banner-content a {
      border-bottom: 1px solid #2CD5C4;
    }

    .exlpore-head h2 {
      font-size: 24px;
      line-height: 33px;
    }

    .exlpore-head-main {
      padding: 20px 0 30px 0;
    }

    .etohs-content {
      padding: 25px 16px 30px 21px;
    }

    .etohs-content h3 {
      font-size: 24px;
      line-height: 24px;
      margin: 0 0 10px 0;
    }

    .etohs-content p {
      font-size: 16px;
      line-height: 24px;
    }

    .etohs-main {
      margin-bottom: 32px;
      margin-top: 25px;
    }

    #clinical-data-accordion h5.accordion_title {
      font-size: 23px;
      line-height: 28px;
    }

    #clinical-data-accordion #clinical-data-two-accordion {
      border-bottom: #E8EAE8 2px solid;
    }

    .clinical-button-tab2 .sample-button-block {
      padding: 34px 0 38px 0;
    }

    .event-treat h4 {
      font-size: 24px;
      line-height: 33px;
    }

    .additional-severe h5 {
      font-size: 24px;
      line-height: 30px;
    }

    .event-view {
      padding: 0 0 20px 0;
    }

    .additional-severe {
      padding: 0 0 25px 0;
    }

    .additional-exacerbation p {
      padding-right: 0;
      font-size: 18px;
      line-height: 24px;
    }

    .additional-exacerbation {
      padding: 0 0 25px 0;
    }

    .event-nnt {
      padding: 24px 0px 10px 0;
    }

    .ethos-design {
      padding: 22px 20px 22px 20px;
    }

    .ethos-design h3 {
     font-size: 23px;
      line-height: 26px;
      margin: 0 0 15px 0; text-transform: uppercase; 
      font-family: 'Avenir-Roman';
    }

    .pulmonary-chronic p {
      font-size: 14px;
      line-height: 20px;
    }

    .pulmonary-chronic {
      padding: 22px 0 30px 0;
    }

    .mortality-content {
      padding: 20px 0 40px 0;
    }

    .mortality-head h3 {
      font-size: 24px;
      line-height: 33px;
    }

    .mortality-head p {
      font-size: 24px;
      line-height: 33px;
    }

    .mortality-head {
      padding: 0 0 30px 0;
    }

    .mortality-population {
      padding: 0 0 10px 0;
    }

    .mortality-incidence {
      background-color: #fff;
      padding: 0;
    }

    .mortality-incidence p {
      font-family: 'Avenir-Book';
      font-weight: normal;
    }

    .clinical-kronos {
      margin-top: 0;
      margin-bottom: 40px;
      padding: 27px 16px 27px 20px;
    }
 
    .clinical-kronos-list h3 {
      font-size: 18px;
      line-height: 24px;
      margin: 0 0 10px 0;
    }
 
    #clinical-data-accordion .cmp-accordion__button {
      padding: 15px 10px 0 0;
    }

    #clinical-data-accordion .cmp-accordion__header {
      padding: 0 0 15px 0;
    }

    .clinical-button-tab3 .sample-button-block {
      padding: 34px 0 36px 0;
    }

    .clinical-kronos-list-first {
      margin: 0 0 25px 0;
    }

    .study-data {
      padding: 15px 0 28px 0;
    }

    .study-data h3 {
      font-size: 18px;
      line-height: 24px;
      margin:0 0 3px 0;
    }

    .study-limitations h3 {
      font-size: 18px;
      line-height: 20px;
      margin: 0 0 10px 0;
    }

    .data-annualized-head h3 {
      font-size: 18px;
      line-height: 24px; padding-right: 10px;
    }

    .study-limitations {
      padding: 0 0 40px 0;
    }

    .data-annualized-head {
      padding: 0 0 15px 0;
    }

    .data-annualized-graph {
      padding: 0 0 25px 0;
    }

    .retrospective {
      padding:0 0 30px 0;
    }

    .fri-trelegy {
      margin-bottom: 20px;
    }

    .fri-trelegy h3 {
      font-size: 18px;
      line-height: 24px;
      margin: 0 0 12px 0;
    }

    .study-data-lung {
      padding: 8px 0 26px 0;
    }

    .study-limitations-lung {
      padding: 0 0 12px 0;
    }

    .data-lung-head {
      padding:0;
    }

    .data-lung-head h3 {
      font-size: 18px;
      line-height: 24px;
    }

    .lung-chronic {
      padding: 15px 0 0 0;
    }

    .fri-lung-block {
      padding: 0 0 45px 0;
    }

    .therapies-head-main {
      padding: 40px 0 28px 0;
    }

    .kronos-data {
      padding: 25px 21px;
    }

    .kronos-main {
      margin-bottom: 32px;
    }

    .reduction-data-note p {
      font-size: 16px;
      line-height: 24px;
    }

    .reduction-data-head h3 {
      font-size: 24px;
      line-height: 30px;
    }

    .reduction-ratio-block {
      padding: 42px 0 8px 0;
    }

    .reduction-data-note {
      padding: 0 0 15px 0;
    }

    .reduction-ratio-block {
      padding: 40px 0 8px 0;
      display: block;
    }

    .reduction-ratio-view {
      width: 100%;
    }

    .reduction-ratio-content {
      width: 100%;
      padding: 10px 0 0 0;
    }

    .reduction-ratio-content h3 {
      font-size: 22px;
      line-height: 24px;
      margin-top: 18px;
      margin-bottom: 5px;
    }

    .moderate-data-note p {
      text-align: left;
      font-size: 16px;
      line-height: 24px;
    }

    .moderate-data-note {
      padding: 15px 0 22px 0;
    }

    .kronos-study-main {
      margin-top: 24px;
      margin-bottom: 30px;
    }

    .kronos-study-content {
      padding: 25px 15px 29px 20px;
    }

    .kronos-study-content h3 {
      font-size: 18px;
    line-height: 22px;
    }

    .kronos-footnote {
      padding: 0 0 9px 0;
    }

    .clinical-button-tab1 .sample-button-block {
      padding:30px 0 50px 0;
    }

    .moderate-severe-tab2 {
      padding: 0 0 20px 0;
    }
 

    .therapies-head h2 {
        font-size: 26px;
        line-height: 30px;
    }

    #copd-clinical-trials-data #effi-word-break {
      word-break: break-all;
    }

    .reduction-ratio-view figure img {
      margin: 0 auto;
      max-width: 202px;
    }

    .data-annualized-view figure img {
      width: 100%;
    }

    #clinical-data-accordion #primary-accordian {
      margin: 18px 0 0 0;
    }

    #clinical-data-accordion #primary-accordian .cmp-accordion__item {
      border-top: #E8EAE8 2px solid;
    }

    .lung-graphic-note {
      padding: 10px 0 8px 0;
    }

    .sample-button-order-data1 a {
      padding: 19px 33px 19px 33px;
    }

    .kronos-data h3 {
      font-size: 18px;
      line-height: 24px; margin: 0 0 8px 0;
    }

    /*  US-106667 - BREZTRI HCP Website January 2026 Update Style starts here */
    .efficacy-banner-main {
      background-image: url(/content/dam/intelligentcontent/brands/breztri-hcp/us/en/images/phase2/mobile/safety-mob-banner.png);
      background-position: left center;
      background-size: cover;
      min-height: 280px;
    }

    .etohs-content h3 {
      font-size: 18px;
      line-height: 22px;
    }

    .exacerbation-mortality-head h2 {
      font-size: 26px;
      line-height: 30px;
      padding: 0 0 30px 0; text-align: center;
    }

    .exacerbation-mortality-head p {
      font-size: 20px;
      line-height: 24px;
      padding: 0 0 13px 0;
    }

    .exacerbation-mortality-head h3 {
      font-size: 23px;
      line-height: 28px;
    }

    .hazard-ratio {
      padding: 30px 0 0 0;
    }

    .hazard-ratio p { font-family: Helvetica;
      font-size: 10px;
      line-height: 12px;
      padding: 7px 0 22px 0; 
    }

    .mortality-ratio-content {
      padding: 0;
    }

    .exacerbation-severe {
      padding: 0;
    }

    .ethos-design {
      margin-top: 28px;
      padding: 24px 20px 28px 20px;
    }

    .exacerbation-budesonide { 
      padding:30px 10px 10px 20px;
    }

    .clinical-button-tab2 .sample-button-block {
      padding: 30px 0 38px 0;
    }

    .data-annualized-head p {
      font-size: 18px;
      line-height: 24px;
    }

    .data-annualized-head {
      padding: 0 0 30px 0;
    }

    .data-lung-head h3 { 
     font-size: 20px;
     line-height: 24px;
      color: #373A36; 
      padding: 0 0 35px 0; 
      letter-spacing: -0.4px;
    }

    .data-lung-head h5 {
      font-size: 20px;
      line-height: 24px;
      padding: 0 0 8px 0;
    }

    .data-lung-head p {
      padding: 0; font-size: 20px;
    line-height: 24px;
    }

    .study-data {
      padding: 15px 0 30px 0;
    }

    .strange {
      padding: 0px 14px 5px 0;
    }

    .study-data-lung {
      padding: 8px 0 24px 0;
    }

    .study-limitations-lung {
      padding: 0 0 30px 0;
    }

    .lung-lama {
      padding: 20px 0 20px 0;
    }

    #copd-clinical-trials-data #clinical-data-accordion #clinical-data-two-accordion {
      border-bottom: 2px transparent solid;
    }

    #copd-clinical-trials-data #resources-tabs::before {
      height: 100%;
    }

    #copd-clinical-trials-data #resources-tabs::after {
      height: 100%;
    }

    .fri-lung-block {
      padding: 0;
    }

    .lung-graphic-note {
      padding: 0 0 0 0;
    }

    body .popup-clinical.modal.cmp-modal__modalbox .modal-box {
      border-radius: 17px;
      max-width: 1172px;
      width: 100%;
      top: 60px;
    }


    body .popup-clinical.modal.cmp-modal__modalbox .modal-box .modal-box__content {
      overflow-y: inherit;
    }

    body .popup-clinical.modal.cmp-modal__modalbox .modal__close {
      height: 35px;
      width: 100%;
      top: -4px;
    }

    body .popup-clinical.modal.cmp-modal__modalbox .modal__closeIcon {
      margin-right: 0;
      width: 74px;
    }

    body .popup-clinical.modal.cmp-modal__modalbox .modal__close svg {
      background-image: url(/content/dam/intelligentcontent/brands/breztri-hcp/us/en/images/phase2/mobile/efficacy/close_icon.svg);
      background-repeat: no-repeat;
      padding: 0;
      width: 74px;
      height: 74px;
      background-size: 74px 74px;
    }

    .clinical-popup-view figure img {
      width: 100%;
    }

    .clinical-popup-container {
      padding: 0 15px;
      max-width: 100%;
    }

    .clinical-popup-head h2 {
      font-size: 24px;
      line-height: 30px; margin: 0 0 5px 0;
    }

    .clinical-popup-head p {
      font-size: 20px;
      line-height: 24px;
    }

    .clinical-popup-head {
      padding: 0 0 30px 0;
    }

    .clinical-data-popup {
      padding: 0 0 40px 0;
    }

    .clinical-popup-two .clinical-popup-head h2 {
      max-width: 300px;
    } 

    .clinical-popup-two .clinical-popup-head {
      padding: 0 0 15px 0;
    }

    .clinical-popup-note {
      padding: 40px 0 0 0;
    }

    .clinical-popup-two .clinical-data-popup {
      padding: 0 0 20px 0;
    }

    .therapies-head-main {
      padding: 24px 0 28px 0;
    }

    .kronos-main {
      margin-bottom: 60px;
    }

    .breztri-therapy-veiw {
      display: block;
    }

    .breztri-popup-veiw {
      width: 100%;
    }

    .breztri-therapy-veiw::after {
      display: none;
    }

    a.popup-therapy {
      right: -15px;
      top: -45px;
    }

    a.popup-therapy img {
      max-width: 86px;
    }

    .therapy-reduction p.therapy-rate {
      font-size: 18px;
      line-height: 24px;
    }

    .therapy-reduction p.therapy-estimate {
      line-height: 24px;
    }

    .therapy-reduction p.therapy-rate::after {
      max-width: 247px;
    }

    .therapy-reduction {
      padding: 25px 0 30px 0;
      margin-bottom: 37px;
      position: relative;
    }

    .therapy-reduction::after {
      content: '';
      background-color: #B4B8B2;
      height: 2px;
      width:86%;
      position: absolute;
      bottom: 0;
      left: 0;
      right: 0;
      margin: 0 auto;
    }

    .therapy-reduction p.therapy-rate {
      margin: 0 0 18px 0;
      padding: 0 0 20px 0;
    }
    .kronos-footnote { padding: 20px 0 10px 0;}
    .muscarinic { padding: 10px 15px 20px 20px;}
    .aerosphere { padding: 0 5px 0 15px; }
    .reduction-data-head { padding: 0 0 32px 0;}
    .breztri-therapy { max-width: 460px;  margin: 0 auto; padding: 0;}

 .clinical-popup-note p span { font-size: 16px; line-height: 22px;}

 body .popup-clinical.modal.cmp-modal--defaultStyle.modal--visible { padding-left: 20px; padding-right: 20px;}
 .clinical-popup-two .clinical-popup-note { padding: 10px 0 0 0; }

  .therapies-head h2 { font-size: 26px; line-height: 30px; color: #121312; padding:0 10px;} 
.kronos-footnote p   { font-size: 14px; line-height: 20px;}
.demonstrate-head h3 { font-size: 26px; line-height: 30px; max-width: 360px;
 margin: 0 auto;}
.demonstrate-main { padding: 22px 0 35px 0;}
.kronos-study-content p { font-size: 16px; line-height: 24px;}
.mortality-ratio-content p { line-height: 24px; padding: 0 0 26px 0; }
p.withdrawal { padding: 0 0 10px 0; }
.exacerbation-budesonide p { font-size: 12px; line-height: 14px; }
.efficacy-drug h3 { font-size: 20px;  line-height: 24px; margin:20px 0 10px 0;}
.efficacy-drug p { font-size: 16px;  line-height: 22px;}
 .data-annualized-content { padding: 0 0 13px 20px; }
.deposition p { color: #373A36;}
.dimensional p { font-size: 12px; line-height: 14px;}
#clinical-data-accordion h5.orestes { max-width:100%;}
.fri-trelegy h3 { font-size: 20px; line-height: 24px;}
.study-data-lung { margin: 0 0 8px 0; }
 .lung-chronic p { font-size: 13px; line-height: 16px;}
 .data-lung-view-first figure { margin: 0 auto; max-width: 500px;}

 .exacerbation-daily { margin-top: 30px; padding: 0 0 0 15px; }
 .exacerbation-daily p { font-size: 12px;  line-height: 14px;}
 /*  US-106667 - BREZTRI HCP Website January 2026 Update Style end here */

  }

  @media screen and (max-width: 767px) {

    .kronos-data {
      padding: 25px 20px;
    }

    #copd-clinical-trials-data .reference {
      padding: 40px 12px 60px 15px;
    }
    .exacerbation-mortality-head h3 { word-spacing: -0.5px;}
    #clinical-data-accordion h5.orestes { font-size: 22px;}
    .demonstrate-head h3 { font-size: 25px;}
  }

  @media screen and (max-width: 677px) { 

    .event-treat h4 {
      max-width: 280px;
    }

    .additional-severe h5 {
      max-width: 332px;
      margin: 0 auto;
    }

    .mortality-head p {
      max-width: 298px;
      margin: 0 auto;
    }

    .mortality-incidence p {
      letter-spacing: -0.1px;
    }

    #copd-clinical-trials-data #clinical-data-accordion .cmp-accordion__icon {
      top: -11px;
    }
 
    #clinical-data-accordion h5.accordion_title {
      max-width: 280px;
    }

    #clinical-data-accordion #primary-accordian h5.accordion_title {
      max-width: 200px;
    }
     #clinical-data-accordion h5.orestes { max-width:100%;}
     .data-lung-view-first figure { max-width:100%;}
     .demonstrate-main .clinical-data-container { padding: 0 10px; }
     .study-data-lung p { letter-spacing: -0.1px;}
     .data-lung-head h3 { font-size: 19.2px;}
     
  }

  @media screen and (max-width: 475px) {
    .reduction-data-head h3 {
      letter-spacing: -0.6px;
    }
    .efficacy-banner-content h1
    {
        max-width: 300px;
    }
  }

  /*US-102140 Breztri HCP Phase 1 NPP Website & Phase 2 Efficacy Updates style ends here*/